Lex's relationship with Deities was complex. To say that every Deity he had encountered was his enemy would be false - some of them even worked for him. Orin the Deity of Hammers from the Midnight Realm, Vinei the Deity of Darkness from the Crystal realm, and Bob were all Deities that he had good relationships with.
However, to date, the strongest and most vile characters Lex had ever faced were also Deities. Ra and his daughter Sekhmet were responsible for so many of the problems he faced. Ironically, Bastet, Ra's other daughter, was Lex's first guest and the one responsible for him getting Regal Embrace.
Then again, there was also the HOA, an organisation of what Lex assumed to be evil, exiled Deities who were dedicated to doing evil stuff.
In short, while not all Deities were bad, they all warranted caution when dealing with them for they weren't exactly simple characters.
