This was Heracles' miscalculation. He had no real understanding of what lurks in the darkness. No matter how adept he was at calculation, he was still limited by human flaws, unable to foresee the unknown.
Shackles may restrain mortals, but they cannot bind monsters.
Lorenzo forcefully threw the shotgun, knocking down a man who was trying to draw his weapon. Then he grabbed the spoon on the table, broke it, and clenched it tightly, the tip protruding from his fingertip like an improvised knuckle duster.
The strength of the sedative could put down a normal adult, but although Lorenzo was an adult, he wasn't quite normal. The numbness didn't limit him much.
Though his reactions slowed, Lorenzo remained lethal to ordinary people. He punched violently, hitting a thug in the throat. Under this force, the spoon between his fingers pierced through the skin and into the flesh.
